Pharmacodynamic principles guide antibiotic efficacy. Time-dependent antibiotics have a prolonged post-antibiotic effect, while concentration-dependent antibiotics require high concentrations to kill bacteria. AUC (area under the curve) and T>MIC (time above the minimal inhibitory concentration) are crucial parameters. Understanding these principles aids in optimizing antibiotic selection, ensuring that the right antibiotic is administered at the appropriate dosage and schedule for maximum effectiveness, thereby combating the growing challenge of antibiotic resistance.
