Hydrophilicity, a measure of an entity’s affinity for water, arises from its polarity and ability to form hydrogen bonds. Molecules with high hydrophilicity (score 10) possess the strongest attraction to water, such as inorganic ions and simple sugars. Biomolecules (score 9) exhibit moderate hydrophilicity due to their polar nature and presence of charged or hydrogen-bonding groups. Certain structures and cell components (score 8) can also exhibit partial hydrophilicity, enabling them to interact with both water and nonpolar molecules.
