In Colonial America, a confluence of factors contributed to the high mortality rates. Demographic differences between colonists and Native Americans rendered them susceptible to diseases, especially smallpox and measles. Harsh environmental conditions, including food shortages and contaminated water, further weakened their resilience. Moreover, accidents and animal attacks added to the toll. This interplay of human vulnerability, disease transmission, and environmental stressors decimated the population, leaving a profound legacy that still informs our understanding of public health and disease risks.
