Antiparallel Beta Sheets: Enhanced Structural Stability

Antiparallel beta sheets, where adjacent strands run in opposite directions, are generally more stable than parallel beta sheets due to their favorable hydrogen bonding patterns. The hydrogen bonds in antiparallel sheets are both parallel and antiparallel to the sheet surface, promoting stability through cooperativity. Additionally, antiparallel sheets tend to have a higher degree of hydrophobic interactions within the core, further contributing to their stability.

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